- Author:
- Weiwei Ai <wai484@aucklanduni.ac.nz>
- Date:
- 2025-08-25 14:11:56+12:00
- Desc:
- Add models
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/d5c/rawfile/b362d194e868c583a529a534dda6c54a5bd4a9e7/Simulation protocols.txt
Simulation protocols for GLUT_BG.sedml:
1. As $g_i$ increases from 1 to 30 mM, the steady-state values of $v_{r1}, v_{r2}, v_{r3},$ and $v_{r4}$ shift from positive (indicating transport from extracellular to intracellular) to negative (indicating transport from intracellular to extracellular). xlim [0, 0.02]
2. As $K_{Ai}$ increases from 149.65 to 500 per fmol, a negative flow rate (from intracellular to extracellular) is observed when $g_i = g_o$, indicating thermodynamically inconsistent parameters.
3. As $\kappa_{r1}$ increases from 0.36 to 100 fmol/s, the rate of change of $q_1, q_2, q_3,$ and $q_4$ becomes faster, while the steady-state distribution of $q$ (the conformational states of the transporter) remains unchanged.
4. As $K_1$ increases from 1.99 to 20 per fmol, the steady-state distribution of $q$ is altered.
Simulation protocols for GLUT_ss_io.sedml:
1. As $g_o$ changes from 1 to 50 mM, the steady-state values of $v$ shift from negative (indicating transport from intracellular to extracellular) to positive (indicating transport from extracellular to intracellular).
2. As $K_{Ai}$ increases from 149.65 to 500 per fmol, a negative flow rate (from intracellular to extracellular) is observed when $g_i = g_o$, indicating thermodynamically inconsistent parameters.
3. As $\kappa_{r1}$ increases from 0.36 to 100 fmol/s, the v_max doesn't change, while the MM constant changes.
